ARES Clinical Studies:
ARES is the most highly validated, highly rated Level III portable monitor on the market. Results from the multi-site ARES Validation Study was published in the journal Chest in October 2005. The independent validation study, conducted at the New York University Sleep Disorders Center published in the Journal of Clinical Sleep Medicine in February 2008. In combination, over 380 comparisons have been made between laboratory polysomnography and the ARES when worn concurrently, and 280 cases when the ARES was applied by a patient and worn in the home. Over 20% of these cases included individuals who had NOT been referred to a sleep laboratory and were presumed to have no prior probability of OSA. The average equipment failure rate across the two studies was less than 3%.
The capability of the ARES Screener questionnaire to predict OSA risk and OSA severity was validated with 608 and 850 individuals, respectively, and cross validated in a study of 50 truck drivers appeared in Sleep Diagnosis and Therapy in April 2007. A cross validation study of the ARES Screener in assessing the prevalence of undiagnosed OSA in 331 dental patients was published in Sleep and Breathing. In this study, 67% of males and 28% of females were identified with the ARES Screener as having a high pre-test probability (high risk) of having at least mild sleep apnea, over 33% of males and 6% of females surveyed were predicted to have moderate or severe sleep apnea. Confirmatory sleep studies showed a positive predictive value of 96% and 70% of those predicted to have moderate or severe OSA by questionnaire had an AHI greater than 20.
The capability of the ARES to assess treatment outcomes with Mandibular Repositioning Devices (MRD), the identification of predictors of successful MRD therapy and the validation of an algorithm that predicts successful outcome with MRD therapy appeared in Sleep and Breathing in September 2007.
Description and Validation of the Apnea Risk Evaluation System: A Novel method to Diagnose Sleep Apnea-Hypopnea in the Home. Westbrook PR, Levendowski DJ, Cvetinovic M, Zavora T, Velimirovic V, Henninger D, Nicholoson D Chest. 2005 Oct; 128: 2166-2175.
Validation of a Self-applied Unattended Monitor for Sleep Disordered Breathing. Ayappa I, Norman RG, Seelall V, Rapoport DM, J Clin Sleep Med. 2008 4(1): 26-37
Assessment of Obstructive Sleep Apnea Risk and Severity in Truck Drivers: Validation of the Screening Questionnaire. Levendowski DJ, Olmstead R, Popovic D, Zavora T, Carper D, Berka C, Westbrook P. Sleep Diagnosis and Therapy. 2007 April 2:20-30
Prevalence of Obstructive Sleep Apnea Risk in a Population of Dental Patients. Levendowski DJ, Morgan T, Montague J, Metzer V, Berka C, Westbrook PR. Sleep and Breathing. 2008 In press.
In-home Evaluation of the Efficacy and Titration of a Mandibular Advancement Device for Obstructive Sleep Apnea. Sleep and Breathing (2007) 11(3):139-147.